Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | NRAS | P01111 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227428 | 0.84 | GSK3B (0.32) | MAPK8MAPK9MAPK10HRH3CYP3A4 | |
| SCHEMBL4471248 | 0.78 | MAPK8 (0.53) | MAPK8MAPK9MAPK10HRH3CYP3A4 | |
| SCHEMBL2753042 | 0.74 | MAPK8 (0.63) | MAPK8MAPK9MAPK10MAPK1PIK3CD | |
| SCHEMBL2753263 | 0.74 | MAPK8 (0.63) | MAPK8MAPK9MAPK10MAPK1PIK3CD | |
| SCHEMBL4457547 | 0.69 | MAPK8 (0.30) | MAPK8MAPK9MAPK10 | |
| SCHEMBL4458450 | 0.67 | MAPK8 (0.39) | MAPK8MAPK9MAPK10HRH3KDM5B | |
| SCHEMBL2752645 | 0.66 | PIK3CD (0.43) | MAP4K4MAPK8MAPK9MAPK10HRH3 | |
| SCHEMBL4457793 | 0.66 | GSK3B (0.40) | MAPK8MAPK9MAPK10HRH3CYP2C9 | |
| SCHEMBL4465305 | 0.66 | MAPK8 (0.36) | MAPK8MAPK9MAPK10IRAK4 | |
| SCHEMBL14027119 | 0.65 | SLC6A4 (0.32) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178552-B2 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |