Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.55 |
| ▸ | INSR | P06213 | 18/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | BUB1B | O60566 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | NPM1 | P06748 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453827 | 0.90 | ALK (0.68) | ALKINSRKCNH2ZAP70PLK4 | |
| SCHEMBL1546094 | 0.87 | ZAP70 (0.56) | ALKINSRKCNH2ZAP70PLK4 | |
| SCHEMBL30165735 | 0.80 | ALK (0.83) | ALKINSR | |
| SCHEMBL25566208 | 0.80 | ALK (0.83) | ALKINSR | |
| SCHEMBL24853245 | 0.80 | ALK (0.76) | ALKINSRKCNH2ZAP70PLK4 | |
| SCHEMBL1546454 | 0.80 | ALK (0.82) | ALKINSRKCNH2ZAP70PLK4 | |
| SCHEMBL1545649 | 0.77 | ALK (0.84) | ALKINSRKCNH2 | |
| SCHEMBL1546175 | 0.76 | ALK (0.60) | ALKINSRKCNH2ZAP70FGFR2 | |
| SCHEMBL1546092 | 0.76 | ALK (0.67) | ALKINSRKCNH2ZAP70PLK4 | |
| SCHEMBL1013964 | 0.75 | ALK (0.69) | ALKINSRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091918-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008073687-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-06-19 | — | — | WO | disclosed |