Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | WNT1 | P04628 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457897 | 1.00 | MAPK8 (0.67) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4460218 | 0.96 | MAPK8 (0.69) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4453249 | 0.96 | MAPK8 (0.69) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL10227417 | 0.96 | MAPK8 (0.69) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4461004 | 0.94 | MAPK8 (0.66) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4468246 | 0.94 | MAPK8 (0.66) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4453734 | 0.91 | MAPK8 (0.56) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4455952 | 0.91 | MAPK8 (0.56) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4457195 | 0.90 | MAPK8 (0.55) | MAPK8MAPK9MAPK10IRAK4IRAK1 | |
| SCHEMBL4457985 | 0.90 | MAPK8 (0.54) | MAPK8MAPK9MAPK10IRAK4IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178552-B2 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20100069354-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069354-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | MAPK7, MAPK13, MAPKAPK5 | MAPK8 26/4885MAPK9 20/4885MAPK10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.