SCHEMBL4454443

SCHEMBL4454443

COc1ccc(CNS(=O)(=O)c2cccc3c(N)cccc23)cc1OC

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 15/20 0.72
SMN1; SMN2 Q16637 3/20 0.56
LMNA P02545 2/20 0.56
MAPT P10636 1/20 0.56
FABP4 P15090 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4447200 0.99 NSD2 (0.73) NSD2SMN1; SMN2LMNAMAPTFABP4
SCHEMBL4449055 0.90 NSD2 (0.68) NSD2FABP4
Hydrochloric Acid SCHEMBL4445423 0.89 NSD2 (0.69) NSD2FABP4
SCHEMBL4454428 0.88 NSD2 (0.69) NSD2FABP4
Hydrochloric Acid SCHEMBL4443352 0.87 NSD2 (0.69) NSD2FABP4
SCHEMBL4445024 0.84 NSD2 (0.78) NSD2
SCHEMBL4445371 0.84 NSD2 (1.00) NSD2LMNA
SCHEMBL4443002 0.84 NSD2 (0.80) NSD2FABP4
Hydrochloric Acid SCHEMBL6909837 0.83 NSD2 (0.64) NSD2LMNAFABP4
Hydrochloric Acid SCHEMBL4448212 0.83 NSD2 (0.78) NSD2FABP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7547716-B2 Sulfonamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2009-06-16 US claimed