Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.62 |
| ▸ | DPP7 | Q9UHL4 | 19/20 | 0.62 |
| ▸ | DPP8 | Q6V1X1 | 17/20 | 0.62 |
| ▸ | DPP9 | Q86TI2 | 11/20 | 0.62 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069812 | 0.76 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL1069810 | 0.76 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL8312000 | 0.71 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL8313314 | 0.71 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL18711323 | 0.68 | NPC1 (0.59) | DPP4DPP7DPP8DPP9OGA | |
| SCHEMBL3670055 | 0.67 | NPC1 (0.48) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL1261845 | 0.67 | DPP4 (0.62) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL1262576 | 0.66 | DPP4 (0.62) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL18701939 | 0.66 | DPP4 (0.56) | DPP4DPP7DPP8DPP9OGA | |
| SCHEMBL20792856 | 0.64 | DPP4 (0.53) | DPP4DPP7DPP8DPP9OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808168-B1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |