Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14749801 | 1.00 | CRBN (0.40) | CRBNOR51E2FKBP5POLBTOP2A | |
| SCHEMBL5567344 | 0.83 | — | — | |
| SCHEMBL2603220 | 0.81 | TSHR (0.34) | CRBNOR51E2FKBP5TOP2ATOP2B | |
| SCHEMBL2603211 | 0.81 | CRBN (0.36) | CRBNOR51E2FKBP5POLB | |
| SCHEMBL14749813 | 0.81 | CRBN (0.36) | CRBNOR51E2FKBP5POLB | |
| SCHEMBL24456537 | 0.81 | TSHR (0.34) | CRBNOR51E2FKBP5TOP2ATOP2B | |
| SCHEMBL24567762 | 0.81 | TSHR (0.34) | CRBNOR51E2FKBP5TOP2ATOP2B | |
| SCHEMBL15215529 | 0.81 | CRBN (0.36) | CRBNOR51E2FKBP5POLB | |
| SCHEMBL11921331 | 0.80 | TSHR (0.35) | CRBNOR51E2FKBP5 | |
| SCHEMBL7624792 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
| US-8759366-B2 | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8551984-B2 | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120277192-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2012-11-01 | — | — | US | disclosed |
| US-20110245205-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-10-06 | — | — | US | disclosed |
| EP-2010240-A2 | MEDICAL DEVICES HAVING ELECTRICALLY ALIGNED ELONGATED PARTICLES | Boston Scientific Limited (BB) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007103356-A2 | MEDICAL DEVICES HAVING ELECTRICALLY ALIGNED ELONGATED PARTICLES | BOSTON SCIENTIFIC LIMITED (BB) | 2007-09-13 | — | — | WO | disclosed |
| US-20070207182-A1 | Medical devices having electrically aligned elongated particles | BOSTON SCIENTIFIC SCIMED, INC. | 2007-09-06 | — | — | US | disclosed |
| EP-0724570-A1 | AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011231-A1 | AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G. D. SEARLE & CO. (US) | 1995-04-27 | — | — | WO | disclosed |
| EP-0153603-B1 | THERMOSETTING RESIN COMPOSITION, CURED PRODUCT, AND PRODUCTION OF CURED PRODUCT | HITACHI, LTD. (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4638026-A | LACTAM ANTIOZONANT | VULNAX INTERNATIONAL LIMITED (FR) | 1987-01-20 | — | — | US | disclosed |
| US-4607094-A | Thermosetting resin composition from aromatic cyanamide | HITACHI, LTD. (JP) | 1986-08-19 | — | — | US | disclosed |
| US-4448956-A | NYLON MOLDING MATERIAL INCORPORATING A MALEIC ANHYDRIDE-CONJUGATED DIENE; ANIONIC CATALYSTS; IMPACT STRENGTH | THE GENERAL TIRE & RUBBER COMPANY (US) | 1984-05-15 | — | — | US | disclosed |
| US-4414362-A | Preparation of polyamides | THE GENERAL TIRE & RUBBER COMPANY (US) | 1983-11-08 | — | — | US | disclosed |
| US-4368237-A | ORGANIC SOLVENT-FREE | FUJI PHOTO FILM CO., LTD. (JP) | 1983-01-11 | — | — | US | disclosed |
| US-4242783-A | Calender roll for use in super calender for magnetic tapes | FUJI PHOTO FILM CO., LTD. (JP) | 1981-01-06 | — | — | US | disclosed |
| US-4128673-A | Method for super calendering magnetic recording elements | FUJI PHOTO FILM CO., LTD. (JP) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245205-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | SYK, BTK, LCK | CRBN 3165/4885OR51E2 3066/4885FKBP5 3465/4885 |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | CRBN 1022/4885OR51E2 3398/4885FKBP5 3879/4885 |
| US-20120277192-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | SYK, BTK, LCK | CRBN 3165/4885OR51E2 3066/4885FKBP5 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.