Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.58 |
| ▸ | IL6 | P05231 | 3/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457773 | 0.96 | TLR7 (0.58) | TLR7IL6TLR8 | |
| SCHEMBL4456775 | 0.95 | TLR7 (0.58) | TLR7IL6TLR8 | |
| SCHEMBL4471508 | 0.93 | TLR7 (0.59) | TLR7IL6TLR8 | |
| SCHEMBL4462512 | 0.90 | TLR7 (0.56) | TLR7IL6TLR8 | |
| SCHEMBL4556721 | 0.87 | TLR7 (0.60) | TLR7IL6TLR8 | |
| SCHEMBL4461861 | 0.87 | TLR7 (0.58) | TLR7TLR8 | |
| SCHEMBL4558140 | 0.86 | TLR7 (0.56) | TLR7IL6TLR8 | |
| SCHEMBL4454031 | 0.85 | TLR7 (0.56) | TLR7IL6 | |
| SCHEMBL4462564 | 0.84 | TLR7 (0.56) | TLR7IL6 | |
| SCHEMBL4459469 | 0.83 | TLR7 (0.54) | TLR7IL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041135-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | Astra Zeneca AB (SE) | 2009-04-01 | — | — | EP | claimed |
| WO-2008004948-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | claimed |
| EP-2041135-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | Astra Zeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008004948-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |