Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.51 |
| ▸ | AKT2 | P31751 | 15/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674462 | 0.85 | AKT1 (0.54) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL2278490 | 0.81 | AKT1 (0.56) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL2279299 | 0.81 | AKT1 (0.51) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL1674565 | 0.80 | AKT1 (0.46) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL1674712 | 0.77 | AKT1 (0.43) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL10226708 | 0.75 | AKT1 (0.41) | AKT1AKT2KCNH2AKT3FECH | |
| SCHEMBL1674528 | 0.75 | AKT1 (0.54) | AKT1AKT2AKT3FECH | |
| SCHEMBL1674513 | 0.73 | AKT1 (0.54) | AKT1AKT2AKT3FECH | |
| SCHEMBL1561014 | 0.72 | AKT1 (0.53) | AKT1AKT2AKT3FECH | |
| SCHEMBL1674444 | 0.72 | AKT1 (0.51) | AKT1AKT2KCNH2AKT3FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009148916-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2009-12-10 | — | — | WO | disclosed |