Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.88 |
| ▸ | RAF1 | P04049 | 2/20 | 0.88 |
| ▸ | LYN | P07948 | 2/20 | 0.88 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.88 |
| ▸ | EGFR | P00533 | 1/20 | 0.88 |
| ▸ | BRAF | P15056 | 1/20 | 0.88 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.88 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.88 |
| ▸ | AKT1 | P31749 | 1/20 | 0.88 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.73 |
| ▸ | SRC | P12931 | 7/20 | 0.58 |
| ▸ | GSK3A | P49840 | 8/20 | 0.51 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.51 |
| ▸ | SYK | P43405 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092237 | 0.94 | ABL1 (1.00) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL4453255 | 0.93 | ABL1 (0.83) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL6613542 | 0.93 | ABL1 (0.83) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL6609355 | 0.92 | ABL1 (0.81) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL4082365 | 0.92 | ABL1 (0.86) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL6613374 | 0.91 | ABL1 (0.82) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL4091842 | 0.91 | ABL1 (0.82) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL4086488 | 0.91 | ABL1 (0.82) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL4091655 | 0.91 | ABL1 (0.84) | ABL1RAF1LYNMAPK9EGFR | |
| SCHEMBL6609488 | 0.91 | ABL1 (0.84) | ABL1RAF1LYNMAPK9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116245-A2 | EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders | Boehringer Ingelheim International GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |