Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039696 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3039800 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4974115 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3038427 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3035054 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3043039 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4976891 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3039687 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3048622 | 0.87 | POLB (0.62) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4977070 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2PKML3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042490-A2 | Benzimidazole derivatives as vanilloid receptor antagonists | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| CN-1784387-A | Novel benzimidazole derivatives | ASTRAZENECA AB (SE) | 2006-06-07 | — | — | CN | disclosed |