Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.56 |
| ▸ | JAK3 | P52333 | 10/20 | 0.56 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383485 | 0.89 | JAK2 (0.57) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4387000 | 0.89 | JAK2 (0.61) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4378185 | 0.89 | JAK2 (0.61) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4378622 | 0.87 | JAK2 (0.55) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4380462 | 0.86 | JAK2 (0.74) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4387657 | 0.86 | JAK2 (0.74) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4380081 | 0.86 | JAK2 (0.76) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4380085 | 0.86 | JAK2 (0.76) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4384824 | 0.86 | JAK2 (0.57) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4374503 | 0.85 | CDK2 (0.64) | JAK2JAK3JAK1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |