Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.67 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457535 | 1.00 | KCNH2 (0.67) | KCNH2CCR5VNN1MCHR1 | |
| SCHEMBL4468483 | 1.00 | KCNH2 (0.67) | KCNH2CCR5VNN1MCHR1 | |
| SCHEMBL4458743 | 0.92 | KCNH2 (0.67) | KCNH2CCR5 | |
| SCHEMBL4477616 | 0.92 | KCNH2 (0.67) | KCNH2CCR5 | |
| SCHEMBL4458741 | 0.92 | KCNH2 (0.67) | KCNH2CCR5 | |
| SCHEMBL4474101 | 0.86 | KCNH2 (0.58) | KCNH2CCR5VNN1 | |
| SCHEMBL4466197 | 0.86 | KCNH2 (0.58) | KCNH2CCR5VNN1 | |
| SCHEMBL4458667 | 0.85 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL4458669 | 0.85 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL4463828 | 0.85 | KCNH2 (0.69) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050165065-A1 | N-type calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2005-07-28 | — | — | US | claimed |
| US-7507760-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-24 | — | — | US | disclosed |
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | disclosed |
| US-20050165065-A1 | N-type calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165065-A1 | N-type calcium channel blockers | CACNA1B, CACNA1C, CACNA1D | KCNH2 46/4885CCR5 3482/4885VNN1 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.