Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.56 |
| ▸ | OXTR | P30559 | 12/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461757 | 0.92 | HCRTR2 (0.57) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4470460 | 0.92 | HCRTR2 (0.62) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4465547 | 0.91 | HCRTR2 (0.55) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4453370 | 0.91 | HCRTR2 (0.55) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4455961 | 0.90 | HCRTR1 (0.45) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4461806 | 0.89 | HCRTR2 (0.61) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4457677 | 0.88 | HCRTR2 (0.67) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4470059 | 0.87 | HCRTR2 (0.59) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4457085 | 0.87 | HCRTR2 (0.59) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 | |
| SCHEMBL4455651 | 0.86 | HCRTR2 (0.57) | HCRTR2HCRTR1OXTRAVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | claimed |
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258903-A1 | Aminoethane Sulfonamide Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPSR1 | HCRTR2 1/4885HCRTR1 2/4885OXTR 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.