Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458204 | 0.92 | IGF1R (0.62) | IGF1RAURKAAURKB | |
| SCHEMBL11341564 | 0.89 | IGF1R (0.78) | IGF1RAURKAAURKB | |
| SCHEMBL4464176 | 0.88 | IGF1R (0.75) | IGF1RAURKAAURKB | |
| SCHEMBL4458845 | 0.84 | IGF1R (0.74) | IGF1RAURKAAURKBSYK | |
| SCHEMBL11340316 | 0.82 | IGF1R (0.79) | IGF1R | |
| SCHEMBL4466607 | 0.81 | IGF1R (0.70) | IGF1RSYK | |
| SCHEMBL12439838 | 0.80 | IGF1R (0.66) | IGF1RAURKAAURKB | |
| SCHEMBL11342847 | 0.80 | IGF1R (0.74) | IGF1RAURKAAURKBSYK | |
| SCHEMBL4464484 | 0.79 | IGF1R (0.74) | IGF1RAURKAAURKB | |
| SCHEMBL11339853 | 0.78 | IGF1R (0.68) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |