Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188566 | 0.86 | KMT2A (0.66) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL15095973 | 0.81 | KMT2A (0.64) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL189834 | 0.80 | KMT2A (0.52) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL15095988 | 0.78 | KMT2A (0.76) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL189805 | 0.76 | KMT2A (0.84) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL250848 | 0.74 | MAPT (0.53) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL189314 | 0.73 | KMT2A (0.60) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL189003 | 0.72 | KMT2A (0.64) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL189589 | 0.71 | KMT2A (1.00) | KMT2AKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL189587 | 0.69 | KMT2A (0.56) | KMT2AKDM4EALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |