Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | MST1R | Q04912 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15338419 | 0.85 | SRC (0.70) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL30216648 | 0.84 | EGFR (0.63) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL15326133 | 0.84 | FGFR2 (0.60) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL6431113 | 0.84 | FGFR2 (0.60) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL166914 | 0.84 | AXL (0.67) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL3913728 | 0.84 | EGFR (0.63) | FGFR2PDGFRAPDGFRBAXLMET | |
| Hydrochloric Acid SCHEMBL21776567 | 0.83 | AXL (0.66) | FGFR2PDGFRAPDGFRBAXLMET | |
| Hydrochloric Acid SCHEMBL30388215 | 0.83 | AXL (0.66) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL17035605 | 0.83 | AXL (0.66) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL13739661 | 0.82 | SRC (0.60) | FGFR2PDGFRAPDGFRBMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |