Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.46 |
| ▸ | JAK3 | P52333 | 9/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382091 | 0.91 | JAK2 (0.46) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4385021 | 0.81 | JAK2 (0.55) | JAK2JAK3CCNA2CDK2CCNA1 | |
| SCHEMBL4385032 | 0.81 | JAK2 (0.55) | JAK2JAK3CCNA2CDK2CCNA1 | |
| SCHEMBL13588597 | 0.76 | JAK2 (0.44) | JAK2JAK3CCNA2CDK2CCNA1 | |
| SCHEMBL4383238 | 0.75 | JAK2 (0.57) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4377860 | 0.74 | JAK2 (0.56) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4383067 | 0.74 | JAK2 (0.68) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4469914 | 0.73 | JAK2 (0.68) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4459479 | 0.73 | JAK2 (0.68) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL4383216 | 0.73 | JAK2 (0.68) | JAK2JAK3JAK1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |