Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MMP7 | P09237 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456395 | 1.00 | NR1I2 (0.55) | NR1I2DNM1TDP1SMN1; SMN2PSIP1 | |
| Hydrochloric Acid SCHEMBL10968743 | 0.97 | NR1I2 (0.52) | NR1I2DNM1TDP1SMN1; SMN2PSIP1 | |
| SCHEMBL3473284 | 0.93 | NR1I2 (0.50) | NR1I2DNM1TDP1SMN1; SMN2PSIP1 | |
| Hexadecane SCHEMBL29039924 | 0.88 | NR1I2 (0.58) | NR1I2TDP1PSIP1PTGS2ALDH1A1 | |
| SCHEMBL29277540 | 0.88 | NR1I2 (0.54) | NR1I2TDP1PSIP1PTGS2ALDH1A1 | |
| Octane SCHEMBL6565412 | 0.88 | NR1I2 (0.58) | NR1I2TDP1PSIP1PTGS2ALDH1A1 | |
| Dodecane SCHEMBL10478943 | 0.88 | NR1I2 (0.58) | NR1I2TDP1PSIP1PTGS2ALDH1A1 | |
| SCHEMBL4457641 | 0.87 | NR1I2 (0.55) | NR1I2DNM1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4464875 | 0.87 | NR1I2 (0.55) | NR1I2DNM1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10976891 | 0.86 | NR1I2 (0.44) | NR1I2TDP1SMN1; SMN2PSIP1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482333-B2 | Blend of an aromatic polycarbonate, a silica filler, a phosphonium sulfonate, and a mono- or di-phosphate ester of a polyoxyalkylene alkyl or aryl ether; antistatic agents; improved impact strength, fluidity and handling performance without decreasing fire and heat resistances | IDEMITSU KOSAN CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| US-20070213437-A1 | Polycarbonate Resin Composition And Moldings Thereof | IDEMITSU KOSAN CO., LTD (JP) | 2007-09-13 | — | — | US | disclosed |
| EP-0953605-B1 | Flow improved polycarbonate composition | TEIJIN LTD (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-6727294-B2 | RADIATION TRANSPARENT MOLDING MATERIALS | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2004-04-27 | — | — | US | disclosed |
| EP-0640646-B1 | Process for production of stabilized polycarnonate | TEIJIN LTD (JP) | 2002-11-06 | — | — | EP | disclosed |
| EP-1221459-A1 | A stabilized polycarbonate | TEIJIN LIMITED (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-20010034419-A1 | Radiation transparent molding materials | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2001-10-25 | — | — | US | disclosed |
| US-6103856-A | LINEAR AROMATIC POLYCARBONATE WHICH HAS BEEN PREPARED BY REACTING AN AROMATIC DIHYDROXY COMPOUND WITH A CARBONATE PRECURSOR THROUGH SOLUTION OR MELT POLYCONDENSATION AND CYCLIC AROMATIC CARBONATE | TEIJIN LIMITED (JP) | 2000-08-15 | — | — | US | disclosed |
| EP-0953605-A2 | Flow improved polycarbonate composition | TEIJIN LIMITED (JP) | 1999-11-03 | — | — | EP | disclosed |
| US-5668202-A | ADDING ORGANOSULFONATE OR SULFATE STABILIZER AFTER MELT POLYCONDENSATION | TEIJIN LIMITED (JP) | 1997-09-16 | — | — | US | disclosed |
| US-5494952-A | CATALYTIC MELT CONDENSATION OF AROMATIC DIHYDROXY COMPOUND AND A CARBONIC ACID DIESTER UNTIL DESIRED VISCOSITY IS REACHED, THEN MIXING WITH STABILIZER CONTAINING QUATERNARY AMMONIUM OR PHOSPHONIUM SALTS OF ORGANIC SULFONIC ACIDS | TEIJIN LIMITED (JP) | 1996-02-27 | — | — | US | disclosed |
| US-5486555-A | Process for production of stabilized polycarbonate | TEIJIN LIMITED (JP) | 1996-01-23 | — | — | US | disclosed |
| EP-0640646-A1 | Process for production of stabilized polycarnonate | TEIJIN LIMITED (JP) | 1995-03-01 | — | — | EP | disclosed |