SCHEMBL4459312

SCHEMBL4459312

NC(=O)N1C(=O)CNC1=O

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30
PABPC1 P11940 1/20 0.30
BLM P54132 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL727395 0.69 TSHR (0.37) TSHRKDM4EMEN1ALDH1A1CYP3A4
SCHEMBL10655517 0.69
SCHEMBL8500805 0.69 TSHR (0.37) TSHRKDM4EMEN1ALDH1A1CYP3A4
SCHEMBL11471808 0.68 MEN1 (0.35) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL9203162 0.67 TSHR (0.38) TSHR
SCHEMBL7507377 0.66 TSHR (0.38) TSHRALDH1A1
SCHEMBL11701624 0.64
SCHEMBL2241278 0.64
SCHEMBL3649196 0.64
SCHEMBL11852262 0.63 KDM4E (0.31) TSHRKDM4EMEN1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023240379-A1 IMIDAZOLINONE DERIVATIVE AND USE THEREOF 南京医工医药技术有限公司 2023-12-21 WO disclosed
CN-114736197-A Imidazolidinone derivatives and their use 南京医工医药技术有限公司 2022-07-12 CN disclosed
WO-2009064342-A1 SAND BASED FUNGICIDES AND SPREADER APPARATUS FOR TOP DRESSING COMPOSITIONS MICHIGAN STATE UNIVERSITY (US) 2009-05-22 WO disclosed
US-4075004-A HERBICIDES BASF AKTIENGESELLSCHAFT (DT) 1978-02-21 US disclosed
US-4009192-A HERBICIDES BASF AKTIENGESELLSCHAFT (DT) 1977-02-22 US disclosed