Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070212 | 0.82 | MAPK14 (0.49) | MAPK14ALDH1A1BRAFRAF1KDM4E | |
| SCHEMBL4091644 | 0.79 | MAPK14 (0.72) | MAPK14IDH2ALDH1A1BRAFLMNA | |
| SCHEMBL27578812 | 0.79 | MAPK14 (0.44) | MAPK14ALDH1A1BRAFRAF1KDM4E | |
| SCHEMBL7069581 | 0.79 | BRAF (0.53) | MAPK14BRAFRAF1GSK3AABL1 | |
| SCHEMBL4464429 | 0.77 | PIK3CA (0.52) | ALDH1A1KDM4EGSK3ACLK2GSK3B | |
| SCHEMBL4464303 | 0.77 | MAPK14 (0.42) | MAPK14BRAFRAF1KDM4EGSK3A | |
| SCHEMBL27559838 | 0.77 | MAPK14 (0.54) | MAPK14ALDH1A1BRAFLMNARAF1 | |
| SCHEMBL4453272 | 0.76 | BRAF (0.48) | MAPK14BRAFRAF1GSK3AABL1 | |
| SCHEMBL7189256 | 0.75 | RAF1 (0.54) | IDH2BRAFRAF1KDM4EGSK3A | |
| SCHEMBL27559804 | 0.75 | MAPK14 (0.50) | MAPK14BRAFRAF1KDM4EGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116245-A2 | EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders | Boehringer Ingelheim International GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |