Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.62 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460085 | 0.91 | ERBB2 (0.70) | EGFRERBB2 | |
| SCHEMBL4463315 | 0.84 | ERBB2 (0.72) | EGFRERBB2 | |
| SCHEMBL4458822 | 0.83 | ERBB2 (0.73) | EGFRERBB2 | |
| SCHEMBL4468336 | 0.80 | ERBB2 (0.70) | EGFRERBB2 | |
| SCHEMBL3432391 | 0.80 | EGFR (0.88) | EGFRERBB2 | |
| SCHEMBL4470019 | 0.79 | ERBB2 (0.57) | EGFRERBB2KDRRETSRC | |
| SCHEMBL4467463 | 0.78 | ERBB2 (0.73) | ERBB2 | |
| SCHEMBL16075707 | 0.77 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL4466009 | 0.76 | ERBB2 (0.79) | EGFRERBB2 | |
| SCHEMBL3395684 | 0.76 | EGFR (0.85) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585869-B2 | Substituted heterocylces for the treatment of abnormal cell growth | PFIZER, INC. (US) | 2009-09-08 | — | — | US | claimed |