Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.57 |
| ▸ | ABL1 | P00519 | 5/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | BCR | P11274 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | PRKCA | P17252 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461008 | 0.93 | JAK2 (0.63) | JAK2HDAC1HDAC6ABL1PDGFRB | |
| SCHEMBL4384202 | 0.86 | JAK2 (0.69) | JAK2HDAC1HDAC6ABL1PDGFRB | |
| SCHEMBL4381115 | 0.83 | JAK2 (0.76) | JAK2HDAC1HDAC6ABL1PDGFRB | |
| SCHEMBL4381674 | 0.82 | JAK2 (0.76) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4383500 | 0.81 | JAK2 (0.67) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4376481 | 0.80 | JAK2 (0.76) | JAK2HDAC1HDAC6ABL1BCR | |
| SCHEMBL4382278 | 0.79 | JAK2 (0.72) | JAK2HDAC1HDAC6JAK3FLT3 | |
| SCHEMBL4386163 | 0.79 | JAK2 (0.67) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4378552 | 0.77 | IKBKB (0.59) | JAK2HDAC1HDAC6PDGFRBPDGFRA | |
| SCHEMBL4383301 | 0.77 | JAK2 (0.61) | JAK2HDAC1HDAC6PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |