Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.71 |
| ▸ | JAK3 | P52333 | 13/20 | 0.71 |
| ▸ | JAK1 | P23458 | 5/20 | 0.71 |
| ▸ | TYK2 | P29597 | 4/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.71 |
| ▸ | FLT3 | P36888 | 2/20 | 0.71 |
| ▸ | PLK4 | O00444 | 2/20 | 0.71 |
| ▸ | CIT | O14578 | 2/20 | 0.71 |
| ▸ | GAK | O14976 | 2/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.71 |
| ▸ | MARK3 | P27448 | 2/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.71 |
| ▸ | NEK3 | P51956 | 2/20 | 0.71 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.71 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.71 |
| ▸ | ULK3 | Q6PHR2 | 2/20 | 0.71 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 2/20 | 0.71 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764597 | 0.96 | JAK2 (0.69) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378445 | 0.86 | JAK2 (0.95) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378440 | 0.86 | JAK2 (0.95) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378028 | 0.84 | JAK2 (0.75) | JAK2JAK3JAK1TYK2PLK4 | |
| SCHEMBL4383114 | 0.84 | JAK2 (0.72) | JAK2JAK3JAK1TYK2PLK4 | |
| Xl-019 SCHEMBL4382715 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL4379072 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL29366461 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL30925304 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL4380116 | 0.83 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| EP-1979329-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |