Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18826569 | 0.87 | HPGD (0.71) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL8306124 | 0.80 | MEN1 (0.68) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL4455080 | 0.73 | KDM4E (0.73) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL13239551 | 0.73 | MEN1 (0.54) | HPGDMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL3611245 | 0.72 | HSD17B10 (0.51) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL30788074 | 0.72 | ANPEP (0.54) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL3218263 | 0.72 | ANPEP (0.54) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL4543868 | 0.71 | KDM4E (0.53) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL13671328 | 0.70 | MEN1 (0.60) | HPGDMAPTALDH1A1KDM4EGAA | |
| SCHEMBL16569284 | 0.70 | DDB1 (0.82) | ALDH1A1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |