Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466222 | 0.91 | ERBB2 (0.69) | EGFRERBB2 | |
| SCHEMBL4466009 | 0.90 | ERBB2 (0.79) | EGFRERBB2 | |
| SCHEMBL4476645 | 0.88 | EGFR (0.71) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL4468310 | 0.86 | ERBB2 (0.64) | EGFRERBB2 | |
| SCHEMBL4463168 | 0.85 | ERBB2 (0.67) | EGFRERBB2 | |
| SCHEMBL4466087 | 0.85 | EGFR (0.55) | EGFRERBB2 | |
| SCHEMBL3391122 | 0.85 | EGFR (1.00) | EGFRERBB2EPHB4 | |
| SCHEMBL29752064 | 0.85 | EGFR (1.00) | EGFRERBB2EPHB4 | |
| SCHEMBL1333601 | 0.85 | EGFR (0.80) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL14489874 | 0.85 | EGFR (0.80) | EGFRERBB2EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585869-B2 | Substituted heterocylces for the treatment of abnormal cell growth | PFIZER, INC. (US) | 2009-09-08 | — | — | US | claimed |
| US-20040242604-A1 | Substituted heterocycles for the treatment of abnormal cell growth | PFIZER INC | 2004-12-02 | — | — | US | claimed |
| US-7585869-B2 | Substituted heterocylces for the treatment of abnormal cell growth | PFIZER, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20040242604-A1 | Substituted heterocycles for the treatment of abnormal cell growth | PFIZER INC | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242604-A1 | Substituted heterocycles for the treatment of abnormal cell growth | CCNA1, CCNT1, CCNY | EGFR 166/4885ERBB2 1183/4885EPHA2 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.