Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL8930746 | 1.00 | TP53 (0.44) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL446197 | 1.00 | TP53 (0.44) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL9250496 | 0.97 | — | — | |
| L-Lactic Acid SCHEMBL3458055 | 0.97 | — | — | |
| L-Lactic Acid SCHEMBL4510537 | 0.97 | TP53 (0.47) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL10791430 | 0.97 | TP53 (0.47) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL5182015 | 0.93 | CA4 (0.44) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL31753630 | 0.93 | — | — | |
| L-Lactic Acid SCHEMBL11097690 | 0.93 | TP53 (0.44) | TP53CA1CA2CA4CYP3A4 | |
| L-Lactic Acid SCHEMBL7999572 | 0.93 | TP53 (0.50) | TP53CA1CA2CA4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611438-B1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2020-04-01 | — | — | EP | disclosed |
| EP-2410981-B2 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20180153996-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2018-06-07 | — | — | US | disclosed |
| EP-3184099-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | Pulmatrix, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2410981-B1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX INC (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9238005-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-9233158-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20150335573-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-11-26 | — | — | US | disclosed |
| US-20150250875-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. | 2015-09-10 | — | — | US | disclosed |
| US-9119778-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20150196486-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-07-16 | — | — | US | disclosed |
| US-9061352-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20130213398-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2013-08-22 | — | — | US | disclosed |
| US-20120064126-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. (US) | 2012-03-15 | — | — | US | disclosed |