Sugi Predict

Sugi Predict / Compounds / SCHEMBL4462142

SCHEMBL4462142

SCHEMBL4462142

O=C1NN=C(NC(=O)c2ccccc2)/C1=C1\C=Cc2ccccc2N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.37
▸ MEN1 O00255 4/20 0.37
▸ KMT2A Q03164 4/20 0.37
▸ GAA P10253 2/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ STAT3 P40763 1/20 0.37
▸ LMNA P02545 1/20 0.36
▸ CASP3 P42574 3/20 0.36
▸ JAK2 O60674 1/20 0.35
▸ TYK2 P29597 1/20 0.35
▸ HCAR3 P49019 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ GSK3B P49841 1/20 0.34
▸ PABPC1 P11940 1/20 0.34
▸ CCR6 P51684 1/20 0.34
▸ ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4462146 1.00 MAPT (0.37) MAPTMEN1KMT2AGAANPC1
SCHEMBL4462878 0.85 MAPT (0.38) MAPTMEN1KMT2AGAARAB9A
SCHEMBL4462876 0.85 MAPT (0.38) MAPTMEN1KMT2AGAARAB9A
SCHEMBL4467058 0.84 SMN1; SMN2 (0.41) MAPTMEN1KMT2AGAANPC1
SCHEMBL4467054 0.84 SMN1; SMN2 (0.41) MAPTMEN1KMT2AGAANPC1
SCHEMBL4464531 0.84 KDM4A (0.42) MAPTMEN1KMT2AGAARAB9A
SCHEMBL4474657 0.83 SMN1; SMN2 (0.39) MAPTGAARAB9ASMN1; SMN2ALDH1A1
SCHEMBL4474662 0.83 SMN1; SMN2 (0.39) MAPTGAARAB9ASMN1; SMN2ALDH1A1
SCHEMBL4470643 0.77 MAPT (0.42) MAPTMEN1KMT2AGAANPC1
SCHEMBL4470653 0.77 MAPT (0.42) MAPTMEN1KMT2AGAANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7550598-B2 Kinase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-23 — — US claimed
EP-1778669-A2 KINASE INHIBITORS Takeda San Diego, Inc. (US) 2007-05-02 — — EP claimed
WO-2006023931-A2 KINASE INHIBITORS TAKEDA SAN DIEGO, INC. (US) 2006-03-02 — — WO claimed
US-20060041137-A1 Kinase inhibitors TAKEDA SAN DIEGO, INC. 2006-02-23 — — US claimed
US-7550598-B2 Kinase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-23 — — US disclosed
US-7550598-B2 Kinase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-23 — — US disclosed
US-7550598-B2 Kinase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-23 — — US disclosed
EP-1778669-A2 KINASE INHIBITORS Takeda San Diego, Inc. (US) 2007-05-02 — — EP disclosed
WO-2006023931-A2 KINASE INHIBITORS TAKEDA SAN DIEGO, INC. (US) 2006-03-02 — — WO disclosed
US-20060041137-A1 Kinase inhibitors TAKEDA SAN DIEGO, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060041137-A1 Kinase inhibitors MAP3K19, MAP3K20, MAP3K1 MAPT 2532/4885MEN1 1654/4885KMT2A 897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.