Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 12/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431872 | 0.90 | PIK3CA (0.65) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL1409823 | 0.90 | MTOR (0.75) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4467555 | 0.87 | PIK3CA (0.81) | MTORPIK3CAPIK3CG | |
| SCHEMBL4469617 | 0.87 | PIK3CA (0.62) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1408627 | 0.84 | MTOR (0.61) | MTORPIK3CAPIK3R1PIK3CD | |
| SCHEMBL1409799 | 0.83 | MTOR (0.57) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL4454539 | 0.82 | MTOR (0.64) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4470935 | 0.81 | MTOR (0.63) | MTORPIK3CAPIK3CG | |
| SCHEMBL4464300 | 0.81 | MTOR (0.67) | MTORPIK3CAPIK3CG | |
| SCHEMBL4456907 | 0.81 | MTOR (0.54) | MTORPIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090304692-A1 | Phosphatidylinositol 3 (PI3); Mammalian Target of Rapamycin, mTOR; triazine compounds substituted with either morpholino or tetrahydropyranyl rings on the triazine ring; anticancer agents, atherosclerosis, bone disorders, psoriasis, BPH, pancreatitis, kidney disease | WYETH (US) | 2009-12-10 | — | — | US | claimed |
| US-20090304692-A1 | Phosphatidylinositol 3 (PI3); Mammalian Target of Rapamycin, mTOR; triazine compounds substituted with either morpholino or tetrahydropyranyl rings on the triazine ring; anticancer agents, atherosclerosis, bone disorders, psoriasis, BPH, pancreatitis, kidney disease | WYETH (US) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304692-A1 | Phosphatidylinositol 3 (PI3); Mammalian Target of Rapamycin, mTOR; triazine compounds substituted with either morpholino or tetrahydropyranyl rings on the triazine ring; anticancer agents, atherosclerosis, bone disorders, psoriasis, BPH, pancreatitis, kidney disease | MTOR, PIK3CA, PIK3R3 | MTOR 1/4885PIK3CA 2/4885PIK3R1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.