Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | RAF1 | P04049 | 7/20 | 0.52 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 4/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467857 | 0.91 | RET (0.51) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4467015 | 0.89 | KDR (0.59) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL9105444 | 0.87 | KDR (0.45) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4474992 | 0.86 | RAF1 (0.72) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4467588 | 0.84 | RAF1 (0.55) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4463621 | 0.84 | RET (0.55) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4485725 | 0.81 | RET (0.50) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL14422928 | 0.81 | RAF1 (0.61) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL4474322 | 0.81 | KDR (0.55) | KDRRAF1HIPK4MAPK14BRAF | |
| SCHEMBL6014190 | 0.80 | KDR (0.59) | KDRRAF1HIPK4MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | claimed |
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| US-20070149594-A1 | Pyrrole derivatives | MERCK PATENT GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149594-A1 | Pyrrole derivatives | RAF1, BRAF, ARAF | KDR 2076/4885RAF1 1/4885HIPK4 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.