Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227439 | 0.94 | MAPK8 (0.38) | MAPK8MAPK9MAPK10TLR9TLR8 | |
| SCHEMBL4467752 | 0.92 | MAPK8 (0.39) | MAPK8MAPK9MAPK10LRRK2CHEK1 | |
| SCHEMBL4454330 | 0.92 | MAPK8 (0.39) | MAPK8MAPK9MAPK10LRRK2CHEK1 | |
| SCHEMBL4457260 | 0.90 | MAPK8 (0.36) | MAPK8MAPK9MAPK10TLR9TLR8 | |
| SCHEMBL4459775 | 0.90 | MAPK8 (0.36) | MAPK8MAPK9MAPK10TLR9TLR8 | |
| SCHEMBL4460642 | 0.88 | MAPK8 (0.41) | MAPK8MAPK9MAPK10LRRK2CHEK1 | |
| SCHEMBL4479520 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9MAPK10LRRK2CHEK1 | |
| SCHEMBL4453961 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9MAPK10LRRK2CHEK1 | |
| SCHEMBL4457323 | 0.83 | MAPK8 (0.37) | MAPK8MAPK9MAPK10TLR9TLR8 | |
| SCHEMBL4453416 | 0.83 | MAPK8 (0.37) | MAPK8MAPK9MAPK10TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178552-B2 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20100069354-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069354-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | MAPK7, MAPK13, MAPKAPK5 | MAPK8 26/4885MAPK9 20/4885MAPK10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.