Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.42 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DDT | P30046 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974004 | 0.93 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4RUVBL1 | |
| SCHEMBL3042696 | 0.93 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4RUVBL1 | |
| SCHEMBL4976395 | 0.91 | RXFP1 (0.46) | RXFP1RAF1BRAFTMPRSS4RUVBL1 | |
| SCHEMBL4453735 | 0.91 | POLB (0.47) | POLBMAPTKDM4ELMNA | |
| SCHEMBL4975964 | 0.88 | RXFP1 (0.48) | RXFP1RAF1BRAFTMPRSS4POLB | |
| SCHEMBL3034826 | 0.86 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4POLB | |
| SCHEMBL4977861 | 0.86 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4POLB | |
| SCHEMBL4974192 | 0.86 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4POLB | |
| SCHEMBL4462916 | 0.86 | RXFP1 (0.47) | RXFP1RAF1BRAFTMPRSS4POLB | |
| SCHEMBL4975749 | 0.86 | RXFP1 (0.46) | RXFP1RAF1BRAFTMPRSS4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |