SCHEMBL4465347

SCHEMBL4465347

O=C(NCc1ccc(OC(F)(F)F)cc1)C1c2ccccc2C(=O)N1C[C@H]1CCCO1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 1.00
KCNH2 Q12809 14/20 1.00
SCN5A Q14524 14/20 0.70
KCNQ2 O43526 1/20 0.60
KCNA5 P22460 1/20 0.60
SCN2A Q99250 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4459445 1.00 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL13577811 0.87 SCN9A (0.76) SCN9AKCNH2SCN5AKCNA5
SCHEMBL4332713 0.85 SCN9A (0.83) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4328335 0.82 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL3889439 0.82 SCN9A (0.82) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4325751 0.82 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4323874 0.81 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4339063 0.79 SCN9A (0.83) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4463844 0.79 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL13568314 0.78 SCN9A (0.69) SCN9AKCNH2SCN5AKCNQ2KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO claimed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed