Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.70 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.68 |
| ▸ | FYN | P06241 | 2/20 | 0.68 |
| ▸ | LYN | P07948 | 2/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.68 |
| ▸ | AXL | P30530 | 2/20 | 0.68 |
| ▸ | FRK | P42685 | 2/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.68 |
| ▸ | BLK | P51451 | 2/20 | 0.68 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106204 | 0.92 | KDR (0.65) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL5724635 | 0.88 | KDR (0.53) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4473424 | 0.87 | KDR (0.54) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4466890 | 0.86 | KDR (0.61) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4466558 | 0.84 | RET (0.71) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4463483 | 0.84 | RAF1 (0.64) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4466716 | 0.84 | RAF1 (0.65) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4469341 | 0.83 | BRAF (0.56) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL4470285 | 0.83 | KDR (0.50) | KDRHIPK4RETPLK4AURKA | |
| SCHEMBL29366563 | 0.83 | KDR (1.00) | KDRHIPK4RETPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| US-20070149594-A1 | Pyrrole derivatives | MERCK PATENT GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149594-A1 | Pyrrole derivatives | RAF1, BRAF, ARAF | KDR 2076/4885HIPK4 322/4885RET 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.