Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.77 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.77 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.77 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.77 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474372 | 0.91 | MAPK14 (0.93) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL4464730 | 0.87 | MAPK14 (0.94) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL4469521 | 0.87 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL4459341 | 0.84 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL4460710 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL12424732 | 0.81 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL4106398 | 0.81 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6581558 | 0.81 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13712661 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL828140 | 0.78 | MAPK14 (0.93) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582660-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | C-A-I-R BIOSCIENCES GMBH (DE) | 2009-09-01 | — | — | US | disclosed |
| EP-1539741-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018458-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE-GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |