Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.70 |
| ▸ | BRAF | P15056 | 3/20 | 0.66 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 11/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477127 | 0.92 | FGFR2 (0.60) | FGFR2BRAFRAF1KDRPDGFRA | |
| SCHEMBL4483964 | 0.90 | PDGFRA (0.59) | FGFR2BRAFRAF1KDRPDGFRA | |
| SCHEMBL7485859 | 0.84 | FGFR2 (0.71) | FGFR2BRAFRAF1KDRPDGFRA | |
| SCHEMBL4486796 | 0.84 | FGFR2 (0.78) | FGFR2BRAFRAF1KDRPDGFRA | |
| SCHEMBL4480559 | 0.84 | FGFR2 (0.70) | FGFR2BRAFKDRPDGFRACSF1R | |
| SCHEMBL20216870 | 0.83 | KDR (0.72) | RAF1KDRPDGFRACSF1REGFR | |
| SCHEMBL4472020 | 0.82 | FGFR2 (1.00) | FGFR2KDRPDGFRA | |
| SCHEMBL5825818 | 0.81 | KDR (0.72) | BRAFRAF1KDRPDGFRACSF1R | |
| SCHEMBL1015284 | 0.80 | BRAF (1.00) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL15463594 | 0.80 | BRAF (0.66) | BRAFRAF1KDRCSF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-20050049264-A1 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2005-03-03 | — | — | US | disclosed |
| EP-1447405-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING AUTO-PHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049264-A1 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | FGFR1, FGFR2, FGFR3 | FGFR2 2/4885BRAF 135/4885RAF1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.