Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.61 |
| ▸ | AURKA | O14965 | 5/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | LYN | P07948 | 4/20 | 0.53 |
| ▸ | RET | P07949 | 4/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.53 |
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | FRK | P42685 | 4/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.53 |
| ▸ | CLK2 | P49760 | 4/20 | 0.53 |
| ▸ | BLK | P51451 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533248 | 0.86 | KDR (0.68) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL27923016 | 0.80 | KDR (0.64) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL28803622 | 0.77 | KDR (0.79) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3531647 | 0.77 | KDR (0.82) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3531281 | 0.76 | KDR (1.00) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL31060331 | 0.76 | KDR (1.00) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3525533 | 0.75 | EPHB4 (0.74) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3534175 | 0.75 | KDR (1.00) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL4471357 | 0.74 | EPHB4 (1.00) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3977000 | 0.74 | KDR (0.55) | KDRAURKAAURKBEPHB4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | claimed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | claimed |
| JP-2006528685-A | — | — | 2006-12-21 | — | — | JP | claimed |
| EP-1620094-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004100947-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-25 | — | — | WO | claimed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182868-A1 | Novel chemical compounds | HRAS, VHL, TP53 | KDR 983/4885AURKA 554/4885AURKB 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.