Sugi Predict

Sugi Predict / Compounds / SCHEMBL4471835

SCHEMBL4471835

SCHEMBL4471835

C=CC[C@H](C(N)=O)[C@@H](CC1CC1)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(Cc2cccc(-c3ccc(C)cc3)c2)C1=O

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NOTCH1 P46531 5/20 0.60
▸ RBPJ Q06330 3/20 0.60
▸ OXTR P30559 4/20 0.48
▸ NOTCH3 Q9UM47 2/20 0.45
▸ PSEN1 P49768 1/20 0.45
▸ PSEN2 P49810 1/20 0.45
▸ APH1B Q8WW43 1/20 0.45
▸ NCSTN Q92542 1/20 0.45
▸ APH1A Q96BI3 1/20 0.45
▸ PSENEN Q9NZ42 1/20 0.45
▸ CCKAR P32238 3/20 0.44
▸ CCKBR P32239 2/20 0.44
▸ KCNH2 Q12809 1/20 0.44
▸ XIAP P98170 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4490200 0.97 NOTCH1 (0.58) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4487329 0.97 NOTCH1 (0.58) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4490028 0.93 NOTCH1 (0.58) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL6092723 0.93 NOTCH1 (0.58) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4495342 0.92 NOTCH1 (0.58) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4493397 0.92 NOTCH1 (0.56) NOTCH1RBPJOXTRNOTCH3CCKAR
SCHEMBL4487698 0.91 NOTCH1 (0.72) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4483863 0.91 NOTCH1 (0.56) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4491400 0.90 NOTCH1 (0.56) NOTCH1RBPJOXTRNOTCH3PSEN1
SCHEMBL4490382 0.90 NOTCH1 (0.56) NOTCH1RBPJOXTRNOTCH3PSEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7507815-B2 Succinoylamino lactams as inhibitors of a-β protein production BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2009-03-24 — — US claimed
US-20080293692-A1 SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2008-11-27 — — US claimed
US-6962913-B2 Benzo-1,4-diazepin-2-ones as inhibitors of Aβ protein production BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-08 — — US claimed
US-20050245501-A1 Succinoylamino lactams as inhibitors of A-beta protein production BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-11-03 — — US claimed
US-20030134841-A1 Succinoylamino lactams as inhibitors of A-beta protein production OLSON RICHARD E (US) 2003-07-17 — — US claimed
EP-4314117-A1 METHOD FOR PRODUCING ORGANOPOLYSILOXANES WITH UNSATURATED GROUPS Wacker Chemie AG (DE) 2024-02-07 — — EP disclosed
EP-3694906-A1 MIXTURES OF MD-METHYLPOLYSILOXANES AS HEAT CARRIER FLUID Wacker Chemie AG (DE) 2020-08-19 — — EP disclosed
EP-3535316-A1 PARTICLE FOAMS BASED ON EXPANDED THERMOPLASTIC ELASTOMERS BASF SE (DE) 2019-09-11 — — EP disclosed
EP-3038751-A1 SUPPORTED COMPOSITION AND THE USE THEREOF IN METHODS FOR THE HYDROFORMYLATION OF UNSATURATED COMPOUNDS Evonik Degussa GmbH (DE) 2016-07-06 — — EP disclosed
WO-2015028281-A1 SUPPORTED COMPOSITION AND THE USE THEREOF IN METHODS FOR THE HYDROFORMYLATION OF UNSATURATED COMPOUNDS EVONIK INDUSTRIES AG (DE) 2015-03-05 — — WO disclosed
EP-2655280-A1 DUST REDUCER AGENT FOR DRY MIXERS OF BUILDING MATERIAL FORMULATIONS Wacker Chemie AG (DE) 2013-10-30 — — EP disclosed
WO-2012101187-A1 DUST REDUCER AGENT FOR DRY MIXERS OF BUILDING MATERIAL FORMULATIONS WACKER CHEMIE AG (DE) 2012-08-02 — — WO disclosed
EP-1191920-A2 METHOD FOR PERMANENTLY SHAPING KERATIN FIBRES, AND AGENTS Hans Schwarzkopf GmbH (DE) 2002-04-03 — — EP disclosed
WO-1999058099-A2 METHOD FOR PERMANENTLY SHAPING KERATIN FIBRES, AND AGENTS HANS SCHWARZKOPF GMBH & CO. KG (DE) 1999-11-18 — — WO disclosed
EP-0406248-A1 USE OF DIMETHYLPOLYSILOXANE FOR TREATING DISORDERS OF THE GASTROINTESTINAL TRACT. STEIGERWALD ARZNEIMITTELWERK (DE) 1991-01-09 — — EP disclosed
EP-0396130-A2 Alkenyloxy-functional organosilicon compounds, their preparation and use WACKER-CHEMIE GMBH (DE) 1990-11-07 — — EP disclosed
EP-0359252-A2 Polysiloxane elastomeric curable compositions resistant to fire, track and electrical arcs WACKER-CHEMIE GMBH (DE) 1990-03-21 — — EP disclosed
EP-0331952-A2 Process for the defoaming of aqueous dispersions of polymeric organic bodies by addition of polyoxialkylene-polysiloxane-solventless bulk polymerizates Th. Goldschmidt AG (DE) 1989-09-13 — — EP disclosed
EP-0281985-A2 Process for the solidification of fluid hydrocarbons Basinski, Grzegorz, Dipl.-Ing. (DE) 1988-09-14 — — EP disclosed
EP-0269886-A2 Process for preparing polysiloxanes having silicon-bound basic nitrogen-containing groups Schill & Seilacher GmbH & Co. (DE) 1988-06-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293692-A1 SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION BACE1, APH1A, APP NOTCH1 94/4885RBPJ 1902/4885OXTR 3336/4885
US-20050245501-A1 Succinoylamino lactams as inhibitors of A-beta protein production BACE1, APH1A, APP NOTCH1 94/4885RBPJ 1902/4885OXTR 3336/4885
US-20030134841-A1 Succinoylamino lactams as inhibitors of A-beta protein production APH1A, BACE1, APP NOTCH1 125/4885RBPJ 1850/4885OXTR 3349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.