Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 6/20 | 0.72 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475736 | 0.84 | EPHB4 (1.00) | EPHB4FYNKDRBTK | |
| SCHEMBL3530692 | 0.84 | KDR (0.50) | EPHB4MAP3K11LRRK2EGFRFYN | |
| SCHEMBL3530589 | 0.84 | KDR (0.50) | EPHB4MAP3K11LRRK2EGFRFYN | |
| SCHEMBL4471359 | 0.81 | EPHB4 (1.00) | EPHB4LRRK2FYNAURKAROCK2 | |
| SCHEMBL4467196 | 0.81 | EPHB4 (1.00) | EPHB4FYNKDRAURKBBTK | |
| SCHEMBL3527962 | 0.79 | EPHB4 (0.52) | EPHB4EGFRFYNAURKADYRK3 | |
| SCHEMBL4473618 | 0.78 | EPHB4 (1.00) | EPHB4FYNKDR | |
| SCHEMBL4489673 | 0.78 | EPHB4 (0.68) | EPHB4EGFRFYNAURKADYRK3 | |
| SCHEMBL4469106 | 0.78 | EPHB4 (0.76) | EPHB4FYNKDR | |
| SCHEMBL4461250 | 0.78 | EPHB4 (0.70) | EPHB4FYNPRKD3MAP4K4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | claimed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | claimed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182868-A1 | Novel chemical compounds | HRAS, VHL, TP53 | EPHB4 2484/4885MAP3K11 19/4885LRRK2 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.