Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.74 |
| ▸ | MET | P08581 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.74 |
| ▸ | LTK | P29376 | 1/20 | 0.74 |
| ▸ | GRK5 | P34947 | 1/20 | 0.74 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.74 |
| ▸ | CDK8 | P49336 | 1/20 | 0.74 |
| ▸ | NEK2 | P51955 | 1/20 | 0.74 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.74 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.74 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.58 |
| ▸ | BCL2 | P10415 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943849 | 1.00 | DYRK1A (0.74) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2951047 | 0.90 | DYRK1A (0.60) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2951985 | 0.86 | BCL2L1 (0.62) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2951515 | 0.85 | DYRK1A (0.54) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2950193 | 0.84 | BCL2L1 (0.53) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2949355 | 0.83 | DYRK1A (0.56) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL5741092 | 0.83 | BCL2L1 (0.63) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2944663 | 0.83 | BCL2L1 (0.56) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2950571 | 0.83 | BCL2L1 (0.54) | DYRK1AAURKBCHEK1NTRK1MET | |
| SCHEMBL2947362 | 0.82 | BCL2L1 (0.62) | DYRK1AAURKBCHEK1NTRK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504512-B2 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-03-17 | — | — | US | disclosed |
| EP-1318978-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | ABBVIE INC. | 2004-09-30 | — | — | US | disclosed |
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES | 2002-05-09 | — | — | US | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | DYRK1A 4777/4885AURKB 1847/4885CHEK1 3163/4885 |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | DYRK1A 4792/4885AURKB 2172/4885CHEK1 3294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.