Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468284 | 0.88 | TP53 (0.60) | TP53ALDH1A1RXFP1ADORA2BSMN1; SMN2 | |
| SCHEMBL4469992 | 0.86 | PDE1A (0.59) | PDE1APDE1BPDE1CALDH1A1RXFP1 | |
| SCHEMBL4464164 | 0.85 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE5ATP53 | |
| SCHEMBL4475016 | 0.80 | SMN1; SMN2 (0.52) | TP53ALDH1A1RXFP1ADORA2BSMN1; SMN2 | |
| SCHEMBL4483780 | 0.79 | PDE4A (0.46) | PDE1APDE1BPDE1CPDE5AADORA2A | |
| SCHEMBL4460628 | 0.76 | PDE1A (0.48) | PDE1APDE1BPDE1CALDH1A1ADORA2A | |
| SCHEMBL4558878 | 0.74 | PDE1A (0.54) | PDE1APDE1BPDE1CPDE5AALDH1A1 | |
| SCHEMBL11033822 | 0.74 | PDE1A (0.73) | PDE1APDE1BPDE1CPDE5AALDH1A1 | |
| SCHEMBL11386278 | 0.74 | PDE1A (0.63) | PDE1APDE1BPDE1CADORA2AADORA2B | |
| Dimethylamine SCHEMBL11383856 | 0.73 | PDE1A (0.59) | PDE1APDE1BPDE1CADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550468-B2 | Theophylline and 3-isobutyl-1 methylxanthine based N-7 substituted derivatives displaying inhibitory activities on PDE-5 phospodiesterase | CHEN ING-JUN | 2009-06-23 | — | — | US | disclosed |
| US-20050209242-A1 | Theophylline and 3-isobutyl-1 methylxanthine based N-7 substituted derivatives displaying inhibitory activities on PDE-5 phospodiesterase | CHEN ING-JUN | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209242-A1 | Theophylline and 3-isobutyl-1 methylxanthine based N-7 substituted derivatives displaying inhibitory activities on PDE-5 phospodiesterase | PDE3A, PDE5A, PDE3B | PDE1A 22/4885PDE1B 24/4885PDE1C 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.