Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30122901 | 1.00 | MPL (1.00) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL29654224 | 0.92 | MPL (0.84) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL474677 | 0.85 | MPL (0.74) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL3775075 | 0.81 | MPL (0.68) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL2517425 | 0.80 | MPL (0.67) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL4367505 | 0.80 | HSD17B10 (0.67) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL8700796 | 0.79 | MPL (0.66) | MPLALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL28911453 | 0.79 | MPL (0.65) | MPLALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL1800719 | 0.78 | MPL (0.65) | MPLHSD17B10ALDH1A1RAB9AMAPT | |
| SCHEMBL31006087 | 0.78 | MPL (0.67) | MPLHSD17B10ALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466229-A | P-acylamino benzenesulfonyl compound and application thereof | 上海中医药大学 | 2022-12-13 | — | — | CN | disclosed |
| CN-109293652-B | Substituted thiazole derivative and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-111116575-B | 5-fluoro-2, 4-pyrimidinediamine compound and preparation and application thereof | 浙江工业大学 | 2021-06-15 | — | — | CN | disclosed |
| CN-111116575-A | 5-fluoro-2, 4-pyrimidinediamine compound and preparation and application thereof | 浙江工业大学 | 2020-05-08 | — | — | CN | disclosed |
| CN-110845437-A | Method for preparing 2-aminothiazole compound | 浙江工业大学 | 2020-02-28 | — | — | CN | disclosed |
| CN-108863978-A | A method of by ethylbenzene class compound synthesis thiazolamine cyclics | 河南师范大学 | 2018-11-23 | — | — | CN | disclosed |
| CN-108822056-A | A kind of synthetic method of Novel 2 Amino thiazole ring analog derivative | 河南师范大学 | 2018-11-16 | — | — | CN | disclosed |
| CN-107556264-A | A kind of synthetic method of novel thiazole ring analog derivative | 河南师范大学 | 2018-01-09 | — | — | CN | disclosed |
| CN-107501204-A | A kind of method that 1,3 substituted thiazole cyclics are synthesized by styrene compound | 河南师范大学 | 2017-12-22 | — | — | CN | disclosed |
| CN-107207445-A | Adenosine A3The conditioning agent of acceptor | 帕罗生物制药有限公司 | 2017-09-26 | — | — | CN | disclosed |
| WO-2011076734-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES | EUROSCREEN S.A. (BE) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011076732-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS | EUROSCREEN S.A. (BE) | 2011-06-30 | — | — | WO | disclosed |
| US-7968577-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968577-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-28 | — | — | US | disclosed |
| WO-2010066682-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS | EUROSCREEN S.A. (BE) | 2010-06-17 | — | — | WO | disclosed |
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2010-03-11 | — | — | US | disclosed |
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2010-03-11 | — | — | US | disclosed |
| CN-101659661-A | 2-aryl-3-(tetrahydro-2H-pyran-4-yl)-N-aryl-heterocyclic-propionamide compound, medicinal composition thereof and application thereof | SHANGHAI INST MATERIA MEDICA | 2010-03-03 | — | — | CN | disclosed |
| WO-2008057862-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | AHMED SALEH | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFRKB, NFKB2, NFKBIA | MPL 4448/4885HSD17B10 1359/4885ALDH1A1 4179/4885 |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | HDAC1, HDAC11, HDAC2 | MPL 4798/4885HSD17B10 89/4885ALDH1A1 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.