Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.71 |
| ▸ | TEK | Q02763 | 16/20 | 0.71 |
| ▸ | KIT | P10721 | 15/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470745 | 0.91 | KDR (0.83) | KDRTEKKITAURKA | |
| SCHEMBL4483025 | 0.90 | KDR (0.71) | KDRTEKKITAURKA | |
| SCHEMBL4486582 | 0.90 | KDR (0.71) | KDRTEKKITAURKA | |
| SCHEMBL4466618 | 0.88 | KDR (0.66) | KDRTEKKITAURKA | |
| SCHEMBL4486490 | 0.88 | KDR (0.77) | KDRTEKKITAURKA | |
| SCHEMBL4479927 | 0.87 | KDR (0.70) | KDRTEKKITAURKA | |
| SCHEMBL4474859 | 0.85 | KDR (0.82) | KDRTEKKIT | |
| SCHEMBL4471885 | 0.85 | KDR (0.78) | KDRTEKKIT | |
| SCHEMBL4478965 | 0.85 | KDR (0.83) | KDRTEKKIT | |
| SCHEMBL4477149 | 0.85 | KDR (0.82) | KDRTEKKITAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-B1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBVIE INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-7560552-B2 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES (US) | 2009-07-14 | — | — | US | disclosed |
| US-20040014756-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014756-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABL1, ERBB2, LCK | KDR 425/4885TEK 328/4885KIT 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.