Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498018 | 0.89 | FGFR2 (0.53) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4500986 | 0.87 | HDAC6 (0.76) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4486529 | 0.86 | FGFR2 (0.51) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4486923 | 0.85 | HDAC6 (0.73) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4487071 | 0.84 | GSK3B (0.58) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4487681 | 0.84 | HDAC6 (0.80) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4493253 | 0.84 | FGFR2 (0.60) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4497298 | 0.83 | HDAC6 (0.71) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4488283 | 0.83 | HDAC6 (0.49) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4488328 | 0.82 | HDAC6 (0.66) | HDAC6FGFR1FGFR2FGFR3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |