Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11879327 | 0.85 | MAPT (0.53) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6833524 | 0.84 | MAPT (0.56) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL10784640 | 0.84 | MAPT (0.56) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11579736 | 0.84 | MAPT (0.53) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11878500 | 0.81 | GAA (0.56) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11880298 | 0.81 | MAPT (0.52) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11876436 | 0.81 | GRIN2D (0.63) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4506455 | 0.81 | MAPT (0.64) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4506462 | 0.81 | MAPT (0.64) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9836802 | 0.81 | MAPT (0.62) | MAPTKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501415-B2 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1833820-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASE AND USES THEROF | Vertex Pharmaceuticals Incorporated (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2006-07-20 | — | — | US | disclosed |
| WO-2006071644-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASES AND USES THEROF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-07-06 | — | — | WO | disclosed |
| US-3976643-A | FROM AN ANILINE AND CYANAMIDE | WILLIAM H. RORER, INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | MAP3K20, MAP4K2, MAP4K1 | MAPT 2609/4885KMT2A 3000/4885MEN1 2448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.