Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 14/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | FLT4 | P35916 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923687 | 0.89 | CA12 (0.57) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1923772 | 0.87 | CA12 (0.53) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL13790139 | 0.85 | PDGFRB (0.58) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1923906 | 0.83 | CA12 (0.54) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1923902 | 0.83 | KDR (0.49) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1923742 | 0.83 | KDR (0.58) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1924817 | 0.82 | KDR (0.48) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1924576 | 0.82 | CA12 (0.55) | PDGFRBFLT3AURKBNTRK1RET | |
| SCHEMBL1923690 | 0.82 | CA12 (0.55) | PDGFRBFLT3AURKBNTRK1RET | |
| Hydrochloric Acid SCHEMBL1924264 | 0.81 | CA12 (0.54) | PDGFRBFLT3AURKBNTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045542-A1 | Substituted Pyrroles and Imidazoles, Compositions Containing Same, Manufacturing Process Therefor and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-02-21 | — | — | US | claimed |
| US-7560571-B2 | Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof | AVENTIS PHARMA S.A. (FR) | 2009-07-14 | — | — | US | disclosed |
| US-20080045542-A1 | Substituted Pyrroles and Imidazoles, Compositions Containing Same, Manufacturing Process Therefor and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045542-A1 | Substituted Pyrroles and Imidazoles, Compositions Containing Same, Manufacturing Process Therefor and Use Thereof | WEE1, WEE2, FARS2 | PDGFRB 1594/4885FLT3 132/4885AURKB 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.