Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 14/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.56 |
| ▸ | MET | P08581 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4488357 | 0.99 | PDGFRA (0.60) | PDGFRAFGFR2KDRMETKIT | |
| SCHEMBL4472967 | 0.96 | PDGFRA (0.60) | PDGFRAFGFR2KDRMET | |
| Hydrochloric Acid SCHEMBL4483716 | 0.95 | PDGFRA (0.59) | PDGFRAFGFR2KDRMET | |
| SCHEMBL4475887 | 0.95 | PDGFRA (0.59) | PDGFRAFGFR2KDRMETHDAC1 | |
| Hydrochloric Acid SCHEMBL4480021 | 0.95 | PDGFRA (0.58) | PDGFRAFGFR2KDRMETHDAC1 | |
| SCHEMBL4471841 | 0.94 | PDGFRA (0.65) | PDGFRAFGFR2KDRMETKIT | |
| Hydrochloric Acid SCHEMBL4476484 | 0.93 | PDGFRA (0.64) | PDGFRAFGFR2KDRMETKIT | |
| SCHEMBL4465009 | 0.93 | FGFR2 (0.68) | PDGFRAFGFR2KDRMET | |
| SCHEMBL4482846 | 0.93 | FGFR2 (0.68) | PDGFRAFGFR2KDRMET | |
| Hydrochloric Acid SCHEMBL4465541 | 0.92 | FGFR2 (0.68) | PDGFRAFGFR2KDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | claimed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |