Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476743 | 0.93 | CHRM2 (0.39) | CHRM2CHRM3ADRB2ACKR3HTR7 | |
| SCHEMBL264972 | 0.90 | CHRM2 (0.54) | CHRM2CHRM3ADRB2 | |
| SCHEMBL4483245 | 0.85 | CHRM3 (0.42) | CHRM2CHRM3ADRB2ACKR3 | |
| SCHEMBL265666 | 0.82 | CHRM2 (0.56) | CHRM2CHRM3ADRB2 | |
| SCHEMBL4483254 | 0.80 | CHRM3 (0.41) | CHRM3ADRB2ACKR3 | |
| SCHEMBL4472533 | 0.80 | CHRM2 (0.43) | CHRM2CHRM3ADRB2HTR7HTR1A | |
| SCHEMBL5276987 | 0.77 | CHRM2 (0.56) | CHRM2CHRM3ADRB2 | |
| SCHEMBL4479680 | 0.76 | CHRM2 (0.48) | CHRM2CHRM3ADRB2HTR7HTR1A | |
| SCHEMBL266133 | 0.76 | CHRM3 (0.62) | CHRM2CHRM3 | |
| SCHEMBL265224 | 0.75 | CHRM3 (0.63) | CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632847-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-(3-[3-(4-hydroxybenzylamino)propionylamino]benzoylamino)ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2009-12-15 | — | — | US | disclosed |