Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493777 | 0.92 | ERBB2 (0.56) | ERBB2KCNH2EGFR | |
| SCHEMBL4485874 | 0.90 | ERBB2 (0.55) | ERBB2KCNH2EGFR | |
| SCHEMBL4481509 | 0.89 | ERBB2 (0.54) | ERBB2KCNH2EGFR | |
| SCHEMBL4492852 | 0.87 | ERBB2 (0.56) | ERBB2KCNH2EGFR | |
| SCHEMBL4471971 | 0.86 | ERBB2 (0.73) | ERBB2KCNH2EGFR | |
| SCHEMBL4477103 | 0.86 | ERBB2 (0.73) | ERBB2KCNH2EGFR | |
| SCHEMBL3809425 | 0.83 | ERBB2 (0.55) | ERBB2KCNH2EGFR | |
| SCHEMBL27627674 | 0.83 | ERBB2 (0.55) | ERBB2KCNH2EGFR | |
| SCHEMBL4473084 | 0.82 | ERBB2 (0.53) | ERBB2KCNH2EGFR | |
| SCHEMBL3817146 | 0.82 | ERBB2 (0.69) | ERBB2KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625908-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-12-01 | — | — | US | disclosed |
| US-20070244136-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244136-A1 | Quinazoline Derivatives | ERBB2, ABL1, MKI67 | ERBB2 1/4885KCNH2 3674/4885EGFR 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.