Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.41 |
| ▸ | CLK1 | P49759 | 10/20 | 0.41 |
| ▸ | CLK2 | P49760 | 10/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.41 |
| ▸ | CLK3 | P49761 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928314 | 0.85 | EGFR (0.41) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL4071292 | 0.84 | EGFR (0.41) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL3937340 | 0.83 | STK17B (0.43) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL4066953 | 0.83 | CLK4 (0.40) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL4069658 | 0.81 | EGFR (0.47) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL3940273 | 0.79 | CLK4 (0.39) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL4073217 | 0.79 | CLK4 (0.40) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL4074719 | 0.79 | EGFR (0.46) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL3938276 | 0.78 | CLK4 (0.51) | CLK4CLK1CLK2DYRK1ADYRK1B | |
| SCHEMBL3924440 | 0.78 | CLK4 (0.44) | CLK4CLK1CLK2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042878-A1 | THIENOPYRIMIDYLAMINES AS MODULATORS OF THE EP2 RECEPTOR | BAYER SHERING PHARMA AG (DE) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042878-A1 | THIENOPYRIMIDYLAMINES AS MODULATORS OF THE EP2 RECEPTOR | PTGER2, PTGER1, PTGDR2 | CLK4 4484/4885CLK1 4289/4885CLK2 2307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.