Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 15/20 | 0.87 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468988 | 0.99 | FGFR2 (0.85) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4466866 | 0.96 | FGFR2 (0.80) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4486327 | 0.95 | FGFR2 (0.80) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4471592 | 0.93 | FGFR2 (1.00) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4478491 | 0.93 | FGFR2 (1.00) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4479490 | 0.92 | FGFR2 (0.98) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4487243 | 0.91 | FGFR2 (0.95) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4464922 | 0.90 | FGFR2 (0.82) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4482503 | 0.89 | FGFR2 (0.92) | FGFR2KITPDGFRAKDRPDGFRB | |
| SCHEMBL4480969 | 0.89 | FGFR2 (0.92) | FGFR2KITPDGFRAKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | claimed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| EP-1447405-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING AUTO-PHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-08-18 | — | — | EP | disclosed |